가토 하악골 결손부의 자가골 이식시 혈소판 풍부혈장이 골형성 촉진에 미치는 영향에 관한 연구
Effect Of Platelet-Rich Plasma On Autogenous Bone Graft For Bone Formation In Rabbit
전민수, 임성철, 강태인, 김보균, 송준호, 연병무, 이영우, 노경록, 김다영, 방은오, 김준현, 남정훈, 박영주,
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전민수 ( Jeon Min-Su ) - 한림대학교 의과대학 구강악안면외과학교실
임성철 ( Lim Sung-Chul ) - 조선대학교 의과대학 병리학교실
강태인 ( Gang Tae-In ) - 한림대학교 의과대학 구강악안면외과학교실
김보균 ( Kim Bo-Kyun ) - 한림대학교 의과대학 구강악안면외과학교실
송준호 ( Song Jun-Ho ) - 한림대학교 의과대학 구강악안면외과학교실
연병무 ( Yeon Byoung-Moo ) - 한림대학교 의과대학 구강악안면외과학교실
이영우 ( Lee Young-Woo ) - 한림대학교 의과대학 구강악안면외과학교실
노경록 ( Noh Kyung-Lok ) - 한림대학교 의과대학 구강악안면외과학교실
김다영 ( Kim Da-Young ) - 한림대학교 의과대학 구강악안면외과학교실
방은오 ( Pang Ean-O ) - 한림대학교 의과대학 구강악안면외과학교실
김준현 ( Kim Jun-Hyun ) - 한림대학교 의과대학 구강악안면외과학교실
남정훈 ( Nam Jeong-Hun ) - 한림대학교 의과대학 구강악안면외과학교실
박영주 ( Park Young-Ju ) - 한림대학교 의과대학 구강악안면외과학교실
KMID : 0360120080300020158
Abstract
Purpose : Recently, various materials were developed for enhancing bone formation capacity. Platelet rich plasma(PRP) is an autologous source with several growth factors and obtained by sequestering and concentrating platelets by gradient density centrifugation. This study was to evaluate the effect of PRP on healing of grafted bone.
Materials and methods : Two blood samples were obtained and analysed for measuring platelet counts of normal blood and PRP. In experimental group, two defects of mandibular bone, 10mm in diameter and 4.0mm deep, were created in the mandible and immediately grafted with autogenous bone chips mixed with PRP. In control group, same bone defects were prepared and grafted with autogenous bone chips. Gelform was used for carrier of PRP. 2 weeks, 4 weeks, 8 weeks later, each group was evaluated with histologi-cal and histomorphometric analyses.
Results : According to histological observation, experimental group was showed more anastomosing newly-formed woven bone having osteoblastic activation than control group. According to histomorphometric analysis, there were 9.11% more newly-formed bone volume in experimental group than control group at 2 weeks, 7.91% more at 4 weeks, 20.08% more at 8 weeks.
Conclusion: Our results demonstrated PRP in autogenous bone graft could enhance the bone formation.
키워드
PRP;Autogenous bone
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